Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood

Laker, Rhianna C., Wlodek, Mary E., Wadley, Glenn D., Gallo, Linda A., Meikle, Peter J. and McConell, Glenn K. (2012) Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood. American Journal of Physiology - Endocrinology and Metabolism, 302 10: E1221-E1230. doi:10.1152/ajpendo.00583.2011


Author Laker, Rhianna C.
Wlodek, Mary E.
Wadley, Glenn D.
Gallo, Linda A.
Meikle, Peter J.
McConell, Glenn K.
Title Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood
Journal name American Journal of Physiology - Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0193-1849
1522-1555
Publication date 2012-05-15
Year available 2012
Sub-type Article (original research)
DOI 10.1152/ajpendo.00583.2011
Open Access Status
Volume 302
Issue 10
Start page E1221
End page E1230
Total pages 10
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Formatted abstract
We have previously shown that 4 wk of exercise training early in life normalizes the otherwise greatly reduced pancreatic β-cell mass in adult male rats born small. The aim of the current study was to determine whether a similar normalization in adulthood of reduced skeletal muscle mitochondrial biogenesis markers and alterations in skeletal muscle lipids of growth-restricted male rats occurs following early exercise training. Bilateral uterine vessel ligation performed on day 18 of gestation resulted in Restricted offspring born small (P < 0.05) compared with both sham-operated Controls and a sham-operated Reduced litter group. Offspring remained sedentary or underwent treadmill running from 5–9 (early exercise) or 20–24 (later exercise) wk of age. At 24 wk of age, Restricted and Reduced litter offspring had lower (P < 0.05) skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) protein expression compared with Control offspring. Early exercise training had the expected effect of increasing skeletal muscle markers of mitochondrial biogenesis, but, at this early age (9 wk), there was no deficit in Restricted and Reduced litter skeletal muscle mitochondrial biogenesis. Unlike our previous observations in pancreatic β-cell mass, there was no “reprogramming” effect of early exercise on adult skeletal muscle such that PGC-1α was lower in adult Restricted and Reduced litter offspring irrespective of exercise training. Later exercise training increased mitochondrial biogenesis in all groups. In conclusion, although the response to exercise training remains intact, early exercise training in rats born small does not have a reprogramming effect to prevent deficits in skeletal muscle markers of mitochondrial biogenesis in adulthood.
Keyword Fetal programming
Mitochondrial biogenesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Non HERDC
 
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