Membrane protein structures for rational antimicrobial drug design

Walden, Patricia M., McMahon, Roisin M. and Archbold, Julia K. (2014) Membrane protein structures for rational antimicrobial drug design. Australian Journal of Chemistry, 67 12: 1724-1731. doi:10.1071/CH14333


Author Walden, Patricia M.
McMahon, Roisin M.
Archbold, Julia K.
Title Membrane protein structures for rational antimicrobial drug design
Journal name Australian Journal of Chemistry   Check publisher's open access policy
ISSN 1445-0038
0004-9425
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1071/CH14333
Open Access Status
Volume 67
Issue 12
Start page 1724
End page 1731
Total pages 8
Place of publication Clayton VIC, Australia
Publisher C S I R O Publishing
Collection year 2015
Language eng
Abstract Antibiotic resistance is a major global health threat. Bacteria have developed novel resistance mechanisms to many of the latest generations of antibiotics and there is an urgent need to develop new therapies to combat these infections. Infections that are caused by multi-drug resistant Gram-negative bacteria result in poor prognosis, prolonged illness, and greater costs for health care. Recent research has pointed to several key bacterial membrane proteins as potential targets for drug and vaccine development. However, determination of the structures of these membrane proteins is not a trivial task. Here we review recent breakthroughs of the structural determination of bacterial membrane proteins and their potential for the future rational design of novel antimicrobial therapies.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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