A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

Morice, Alyn H., Jakes, Adam D., Faruqi, Shoaib, Birring, Surinder S., McGarvey, Lorcan, Canning, Brendan, Smith, Jaclyn A., Parker, Sean M., Chung, Kian Fan, Lai, Kefang, Pavord, Ian D., van den Berg, Jan, Song, Woo-Jung, Millqvist, Eva, Farrell, Michael J., Mazzone, Stuart B. and Dicpinigaitis, Peter (2014) A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response. European Respiratory Journal, 44 5: 1149-1155. doi:10.1183/09031936.00217813


Author Morice, Alyn H.
Jakes, Adam D.
Faruqi, Shoaib
Birring, Surinder S.
McGarvey, Lorcan
Canning, Brendan
Smith, Jaclyn A.
Parker, Sean M.
Chung, Kian Fan
Lai, Kefang
Pavord, Ian D.
van den Berg, Jan
Song, Woo-Jung
Millqvist, Eva
Farrell, Michael J.
Mazzone, Stuart B.
Dicpinigaitis, Peter
Title A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
1399-3003
Publication date 2014-11-01
Year available 2014
Sub-type Article (original research)
DOI 10.1183/09031936.00217813
Open Access Status
Volume 44
Issue 5
Start page 1149
End page 1155
Total pages 7
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Collection year 2015
Language eng
Formatted abstract
Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we have reviewed the age and sex of unselected referrals to 11 cough clinics. To investigate the cause of any observed sex dimorphism, functional magnetic resonance imaging of putative cough centres was analysed in normal volunteers.

The demographic profile of consecutive patients presenting with chronic cough was evaluated. Cough challenge with capsaicin was undertaken in normal volunteers to construct a concentration-response curve. Subsequent functional magnetic resonance imaging during repeated inhalation of sub-tussive concentrations of capsaicin observed areas of activation within the brain and differences in the sexes identified.

Of the 10 032 patients presenting with chronic cough, two-thirds (6591) were female (mean age 55 years). The patient profile was largely uniform across centres. The most common age for presentation was 60–69 years. The maximum tolerable dose of inhaled capsaicin was lower in females; however, a significantly greater activation of the somatosensory cortex was observed.

Patients presenting with chronic cough from diverse racial and geographic backgrounds have a strikingly homogeneous demographic profile, suggesting a distinct clinical entity. The preponderance of females may be explained by sex-related differences in the central processing of cough sensation.
Keyword Urge to cough
Gender differences
Reflex sensitivity
Persistent cough
Human brain
Prevalence
Sex
Capsaicin
Symptoms
Pain
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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