Mesenchymal Stem Cell Response to Polyacrylamide Gels of Varying Stiffness

Hudson, James (2006). Mesenchymal Stem Cell Response to Polyacrylamide Gels of Varying Stiffness Honours Thesis, School of Engineering, The University of Queensland.

       
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Author Hudson, James
Thesis Title Mesenchymal Stem Cell Response to Polyacrylamide Gels of Varying Stiffness
School, Centre or Institute School of Engineering
Institution The University of Queensland
Publication date 2006
Thesis type Honours Thesis
Supervisor Justin Cooper-White
Total pages 87
Language eng
Subjects 0904 Chemical Engineering
Formatted abstract
Many of the current treatments for tissue destruction or damage do not restore the full original functionality of the tissues. This has lead to many long term complications associated with these treatments. As a result, tissue engineering is becoming a more viable option to treat or replace damaged tissues as it restores the full functionality of
the tissue.

To the author’s knowledge there has been no data published on how mesenchymal stem cells (MSCs) respond to changes in substrate stiffness. MSCs have very good applications in tissue engineering products as they are able to differentiate into a very wide range of tissues including but not limited to:

• Bone.
• Fat.
• Cartilage.
• Muscle – skeletal, smooth and heart.
• Blood vessels.

Therefore, as tissue engineering technology progresses it is likely that more products will use MSCs. So it is important that MSC response to changes in substrate stiffness be investigated. In this study the dependence of MSCs on substrate stiffness was investigated but only for the proliferation of the MSCs not the differentiation. Also, the MSCs were fixed after 4hrs of culture to ensure that only the initial attachment was investigated and the MSC had not started laying down ECM.

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Keyword Gels of Varying Stiffness

Document type: Thesis
Collection: UQ Theses (non-RHD) - UQ staff and students only
 
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Created: Thu, 18 Dec 2014, 15:36:37 EST by Asma Asrar Qureshi on behalf of Scholarly Communication and Digitisation Service