Wolbachia small noncoding RNAs and their role in cross-kingdom communications

Mayoral, Jaime G., Hussain, M, Joubertb, D. Albert, Iturbe-Ormaetxe, Iñaki, O'Neill, Scott L. and Asgari, Sassan (2014) Wolbachia small noncoding RNAs and their role in cross-kingdom communications. Proceedings of the National Academy of Science of the United States of America, 111 52: 18721-18726. doi:10.1073/pnas.1420131112


Author Mayoral, Jaime G.
Hussain, M
Joubertb, D. Albert
Iturbe-Ormaetxe, Iñaki
O'Neill, Scott L.
Asgari, Sassan
Title Wolbachia small noncoding RNAs and their role in cross-kingdom communications
Formatted title
Wolbachia small noncoding RNAs and their role in cross-kingdom communications
Journal name Proceedings of the National Academy of Science of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2014-12-15
Sub-type Article (original research)
DOI 10.1073/pnas.1420131112
Open Access Status DOI
Volume 111
Issue 52
Start page 18721
End page 18726
Total pages 6
Place of publication Washington, DC, United States
Publisher National Academy of Sciences
Collection year 2015
Language eng
Formatted abstract
In prokaryotes, small noncoding RNAs (snRNAs) of 50–500 nt are produced that are important in bacterial virulence and response
to environmental stimuli. Here, we identified and characterized snRNAs from the endosymbiotic bacteria, Wolbachia, which are
widespread in invertebrates and cause reproductive manipulations. Most importantly, some strains of Wolbachia inhibit replication
of several vector-borne pathogens in insects. We demonstrate that two abundant snRNAs, WsnRNA-46 and WsnRNA-49, are
expressed in Wolbachia from noncoding RNA transcripts that contain precursors with stem-loop structures. WsnRNAs were detected in Aedes aegypti mosquitoes infected with the wMelPopCLA strain of Wolbachia and in Drosophila melanogaster and Drosophila simulans infected with wMelPop and wAu strains, respectively, indicating that the WsnRNAs are conserved across species and strains. In addition, we show that the WsnRNAs may potentially regulate host genes and Wolbachia genes. Our findings provide evidence for the production of functional snRNAs by Wolbachia that play roles in cross-kingdom communication between the endosymbiont and the host.
Keyword Aedes aegypti
Mosquito
microRNA
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print: 15 December 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biological Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Dec 2014, 06:12:21 EST by Prof Sassan Asgari on behalf of School of Biological Sciences