Reciprocal interactions of the SMA and cingulate cortex sustain premovement activity for voluntary actions

Nguyen, Vinh T., Breakspear, Michael and Cunnington, Ross (2014) Reciprocal interactions of the SMA and cingulate cortex sustain premovement activity for voluntary actions. Journal of Neuroscience, 34 49: 16397-16407. doi:10.1523/JNEUROSCI.2571-14.2014

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Author Nguyen, Vinh T.
Breakspear, Michael
Cunnington, Ross
Title Reciprocal interactions of the SMA and cingulate cortex sustain premovement activity for voluntary actions
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 1529-2401
Publication date 2014-12-03
Year available 2014
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.2571-14.2014
Open Access Status File (Publisher version)
Volume 34
Issue 49
Start page 16397
End page 16407
Total pages 11
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Collection year 2015
Language eng
Abstract Voluntary action is one of the core functions of the human brain, and is accompanied by the well known readiness potential or Bereitschaftspotential. A network of cortical areas is responsible for the motor preparation process, including the anterior mid-cingulate cortex (aMCC) and the SMA. However, the relationship between activity in these regions during movement preparation and the readiness potential is poorly understood. We examined this relationship by integrating simultaneously acquired EEG and fMRI through computational modeling. We first observed that global field power of premovement neural activity showed a specific correlation with BOLD responses in the aMCC. We then used dynamic causal modeling to infer premovement interactions between these regions and their relationship to the premovement neural activity underlying the readiness potential. These analyses suggest that SMA and aMCC have strong reciprocal connections that act to sustain each other's activity, and that this interaction is mediated during movement preparation according to the readiness potential amplitude, as reflected in global cortical field power. Our study suggests that the reciprocal connections between SMA and aMCC are important to maintain the sustained activity of the readiness potential before movement and lead to a weak system instability at movement onset. We suggest that the effective connectivity of this network underlies its functional role in the preparation of self-generated actions.
Keyword Anterior mid-cingulate cortex
Multimodal data fusion
Readiness potential
Simultaneous EEG-fMRI
Supplementary motor area
Voluntary action
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Tue, 16 Dec 2014, 02:49:06 EST by System User on behalf of Queensland Brain Institute