Glycation in diabetic nephropathy

Forbes, Josephine M. and Cooper, Mark E. (2012) Glycation in diabetic nephropathy. Amino Acids, 42 4: 1185-1192. doi:10.1007/s00726-010-0771-4


Author Forbes, Josephine M.
Cooper, Mark E.
Title Glycation in diabetic nephropathy
Journal name Amino Acids   Check publisher's open access policy
ISSN 0939-4451
1438-2199
Publication date 2012-04-01
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00726-010-0771-4
Open Access Status Not Open Access
Volume 42
Issue 4
Start page 1185
End page 1192
Total pages 8
Place of publication Wien, Austria
Publisher Springer Wien
Language eng
Abstract The kidney is an extremely complex organ with broad ranging functions in the body, including but not restricted to waste excretion, ion and water balance, maintenance of blood pressure, glucose homeostasis, generation of erythropoietin and activation of vitamin D. With diabetes, many of these integral processes are interrupted via a combination of haemodynamic and metabolic changes including increases in the accumulation of proteins modified by advanced glycation, known as advanced glycation end products (AGEs). Indeed, hyperglycaemia and the redox imbalances seen with diabetes are each independent accelerants for the production of AGEs, which synergistically combine in this disorder. In addition, as kidney function declines, characterised by a loss of glomerular filtration, the excretion of AGEs is decreased, possibly exacerbating renal injury by further elevating the body's tissue and circulating AGE pool. Therefore, it has become apparent that decreasing the accumulation of AGEs or interrupting their downstream effects on the kidney, are desirable therapeutic targets for the treatment of diabetic renal disease.
Keyword Diabetic nephropathy
Advanced glycation
Haemodynamic
Renal
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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