Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models

Low, H., Hoang, A., Forbes, J., Thomas, M., Lyons, J. G., Nestel, P., Bach, L. A. and Sviridov, D. (2012) Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models. Diabetologia, 55 9: 2513-2521. doi:10.1007/s00125-012-2570-9


Author Low, H.
Hoang, A.
Forbes, J.
Thomas, M.
Lyons, J. G.
Nestel, P.
Bach, L. A.
Sviridov, D.
Title Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models
Journal name Diabetologia   Check publisher's open access policy
ISSN 0012-186X
1432-0428
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1007/s00125-012-2570-9
Open Access Status Not yet assessed
Volume 55
Issue 9
Start page 2513
End page 2521
Total pages 9
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
Aims/hypothesis: We investigated the contribution of AGEs to the impairment of reverse cholesterol transport (RCT) variables in diabetic individuals and in two animal models of diabetic obesity and of renal impairment.
Methods: The capacity of plasma and HDL from 26 individuals with moderately controlled type 2 diabetes to support cholesterol efflux was compared with 26 age- and sex-matched individuals without diabetes. We also compared the rates of RCT in vivo in two animal models: db/db mice and mice with chronic renal failure.
Results: Diabetic individuals had characteristic dyslipidaemia and higher levels of plasma AGEs. The capacity of whole plasma, ApoB-depleted plasma and isolated HDL to support cholesterol efflux was greater for diabetic patients compared with controls despite their lower HDL-cholesterol levels. The capacity of plasma to support cholesterol efflux correlated with plasma levels of cholesteryl ester transfer protein and levels of ApoB, but not with levels of AGE. RCT was severely impaired in db/db mice despite elevated HDL-cholesterol levels and no change in AGE concentration, whereas RCT in uraemic mice was unaffected despite elevated AGE levels.
Conclusions/interpretation: AGEs are unlikely to contribute significantly to the impairment of RCT in type 2 diabetes.
Keyword AGE
Cholesterol
Diabetes
HDL
Reverse cholesterol transport
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
School of Medicine Publications
 
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