Renal microvascular injury in diabetes: RAGE and redox signaling

Coughlan, Melinda T., Cooper, Mark E. and Forbes, Josephine M. (2007) Renal microvascular injury in diabetes: RAGE and redox signaling. Antioxidants and Redox Signaling, 9 3: 331-342. doi:10.1089/ars.2006.1469


Author Coughlan, Melinda T.
Cooper, Mark E.
Forbes, Josephine M.
Title Renal microvascular injury in diabetes: RAGE and redox signaling
Journal name Antioxidants and Redox Signaling   Check publisher's open access policy
ISSN 1523-0864
1557-7716
Publication date 2007-02-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1089/ars.2006.1469
Open Access Status Not yet assessed
Volume 9
Issue 3
Start page 331
End page 342
Total pages 12
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Language eng
Abstract Diabetic nephropathy remains a major cause of morbidity and mortality in the diabetic population and is the leading cause of end-stage renal failure in the Western World. Despite current therapeutics including intensified glycemic control and blood pressure lowering agents, renal disease continues to progress relentlessly in diabetic patients, albeit at a lower rate. It is well recognized that metabolic and hemodynamic factors play a central role in accelerating renal disease in diabetes. However, recent experimental studies have suggested that increased generation of reactive oxygen species (ROS) as a result of the diabetic milieu may play a central role in the progression of diabetic microvascular complications. These ROS appear to be generated primarily from mitochondrial sources and via the enzyme, NADPH oxidase. This review focuses on how ROS play a deleterious role in the diabetic kidney and how they are involved in crosstalk among various signaling pathways, ultimately leading to renal dysfunction and structural injury.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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