Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy

Forbes, Josephine M., Thorpe, Suzanne R., Thallas-Bonke, Vicki, Pete, Josefa, Thomas, Merlin C., Deemer, Elizabeth R., Bassal, Sahar, El-Osta, Assam, Long, David M., Panagiotopoulos, Sianna, Jerums, George, Osicka, Tanya M. and Cooper, Mark E. (2005) Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy. Journal of the American Society of Nephrology, 16 8: 2363-2372. doi:10.1681/ASN.2005010062


Author Forbes, Josephine M.
Thorpe, Suzanne R.
Thallas-Bonke, Vicki
Pete, Josefa
Thomas, Merlin C.
Deemer, Elizabeth R.
Bassal, Sahar
El-Osta, Assam
Long, David M.
Panagiotopoulos, Sianna
Jerums, George
Osicka, Tanya M.
Cooper, Mark E.
Title Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy
Journal name Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1046-6673
1533-3450
Publication date 2005-08-01
Sub-type Article (original research)
DOI 10.1681/ASN.2005010062
Open Access Status Not yet assessed
Volume 16
Issue 8
Start page 2363
End page 2372
Total pages 10
Place of publication Washington, DC, United States
Publisher American Society of Nephrology
Language eng
Formatted abstract
Recent studies have identified that first-line renoprotective agents that interrupt the renin-angiotensin system not only reduce BP but also can attenuate advanced glycation end product (AGE) accumulation. This study used in vitro, preclinical, and human approaches to explore the potential effects of these agents on the modulation of the receptor for AGE (RAGE). Bovine aortic endothelial cells that were exposed to the angiotensin-converting enzyme inhibitor (ACEi) ramiprilat in the presence of high glucose demonstrated a significant increase in soluble RAGE (sRAGE) secreted into the medium. In streptozotocin-induced diabetic rats, ramipril treatment (ACEi) at 3 mg/L for 24 wk reduced the accumulation of skin collagen-linked carboxymethyllysine and pentosidine, as well as circulating and renal AGE. Renal gene upregulation of total RAGE (all three splice variants) was observed in ACEi-treated animals. There was a specific increase in the gene expression of the splice variant C-truncated RAGE (sRAGE). There were also increases in sRAGE protein identified within renal cells with ACEi treatment, which showed AGE-binding ability. This was associated with decreases in renal full-length RAGE protein from ACEi-treated rats. Decreases in plasma soluble RAGE that were significantly increased by ACEi treatment were also identified in diabetic rats. Similarly, there was a significant increase in plasma sRAGE in patients who had type 1 diabetes and were treated with the ACEi perindopril. Complexes between sRAGE and carboxymethyllysine were identified in human and rodent diabetic plasma. It is postulated that ACE inhibition reduces the accumulation of AGE in diabetes partly by increasing the production and secretion of sRAGE into plasma. 
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 138 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 158 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 15 Dec 2014, 10:46:29 EST by System User on behalf of Learning and Research Services (UQ Library)