Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood

Zhang, Guicheng, Lai, Ching Tat, Hartmann, Peter, Oddy, Wendy H., Kusel, Merci M. H., Sly, Peter D. and Holt, Patrick G. (2014) Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood. Pediatric Allergy and Immunology, 25 6: 544-551. doi:10.1111/pai.12265

Author Zhang, Guicheng
Lai, Ching Tat
Hartmann, Peter
Oddy, Wendy H.
Kusel, Merci M. H.
Sly, Peter D.
Holt, Patrick G.
Title Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood
Journal name Pediatric Allergy and Immunology   Check publisher's open access policy
ISSN 0905-6157
Publication date 2014-10
Sub-type Article (original research)
DOI 10.1111/pai.12265
Open Access Status
Volume 25
Issue 6
Start page 544
End page 551
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Collection year 2015
Language eng
Formatted abstract
Background:  The impact of breast milk feeding on susceptibility to asthma in childhood is highly controversial, due in part to failure of the majority of studies in the area to adequately account for key confounders exemplified by respiratory infection history, plus the effects of recall bias.

Methods: As part of a prospective cohort study on the role of respiratory infections in asthma development in high-risk children, we measured the concentration of a panel of anti-infective proteins in maternal milk samples and analyzed associations between these and subsequent atopy-, infection-, and asthma-related outcomes prospectively to age 10 years.

Results: We observed significant but transient inverse associations between the concentration of milk proteins and susceptibility to upper respiratory infections in year 1 only, and parallel but positive transient associations with early lower respiratory infections and atopy. No associations were seen with asthma-related outcomes.

Conclusions: Breast milk feeding may influence the expression of inflammatory symptoms associated with respiratory infections and atopy in early life, but these effects appear to be inconsistent and transient. The heterogeneous nature of breast-feeding effects suggests it may influence systemic immunoinflammatory function at several different levels.
Keyword Atopy
Breast feeding
Respiratory infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
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