Effects of polymorphisms in the porcine microRNA miR-1 locus on muscle fiber type composition and miR-1 expression

Hong, Jae-Sang, Noh, Su-Hyun, Lee, Jun-Seong, Kim, Jun-Mo, Hong, Ki-Chang and Lee, Young Sik (2012) Effects of polymorphisms in the porcine microRNA miR-1 locus on muscle fiber type composition and miR-1 expression. Gene, 506 1: 211-216. doi:10.1016/j.gene.2012.06.050


Author Hong, Jae-Sang
Noh, Su-Hyun
Lee, Jun-Seong
Kim, Jun-Mo
Hong, Ki-Chang
Lee, Young Sik
Title Effects of polymorphisms in the porcine microRNA miR-1 locus on muscle fiber type composition and miR-1 expression
Formatted title
Effects of polymorphisms in the porcine microRNA miR-1 locus on muscle fiber type composition and miR-1 expression
Journal name Gene   Check publisher's open access policy
ISSN 0378-1119
1879-0038
Publication date 2012-09-10
Sub-type Article (original research)
DOI 10.1016/j.gene.2012.06.050
Open Access Status Not Open Access
Volume 506
Issue 1
Start page 211
End page 216
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
MicroRNAs (miRNAs) are a group of evolutionarily conserved small noncoding RNAs with regulatory functions. Increasing evidence suggests that polymorphisms in miRNA genes are associated with phenotypic variation by affecting miRNA expression and/or function. Here, we identified two single nucleotide polymorphisms (SNPs) in the porcine miR-1 locus, both of which were linked and located downstream from the stem–loop miRNA precursor sequence within the primary miR-1 region. An association study on muscle fiber characteristics and meat quality traits was performed with a total of 451 pigs representing three pig breeds (Berkshire, n = 153; Landrace, n = 125; Yorkshire, n = 173). The miR-1 SNPs were significantly associated with type I and type IIa muscle fibers in number and area compositions, respectively, but not with meat quality traits. Notably, these polymorphisms were also significantly associated with altered expression of the primary miR-1 transcript, ultimately leading to comparable changes in the levels of both precursor and mature miR-1. Furthermore, altered miR-1 levels were correlated with the variation in muscle fiber composition. Our data suggest that miR-1 may be a candidate gene associated with muscle fiber type composition.
Keyword MiR-1
Muscle fiber type composition
Pig
Polymorphism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Nutrition and Food Sciences Publications
 
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