Cyclotide analysis

Northfield, Susan E., Poth, Aaron, D'Souza, Charlotte and Craik, David J. (2014). Cyclotide analysis. In Robert A. Meyers (Ed.), Encyclopedia of Analytical Chemistry (pp. 1-18) Hoboken, NJ, USA: John Wiley & Sons. doi:10.1002/9780470027318.a9933


Author Northfield, Susan E.
Poth, Aaron
D'Souza, Charlotte
Craik, David J.
Title of chapter Cyclotide analysis
Title of book Encyclopedia of Analytical Chemistry
Place of Publication Hoboken, NJ, USA
Publisher John Wiley & Sons
Publication Year 2014
Sub-type Chapter in reference work, encyclopaedia, manual or handbook
DOI 10.1002/9780470027318.a9933
Open Access Status
ISBN 9780470027318
Editor Robert A. Meyers
Start page 1
End page 18
Total pages 18
Language eng
Formatted Abstract/Summary
This chapter provides an overview of methods for the analysis of cyclotides, a structurally unique class of plant defense peptides. These peptides have been extensively analyzed over the last two decades, having been discovered in the Violaceae, Rubiaceae, Cucurbitaceae, Fabaceae, and Solanaceae plant families. Cyclotides are characterized by their distinctive head-to-tail cyclic peptide backbone and the cystine knot formed by their three conserved disulfide bonds. Cyclotides exhibit a range of activities, including insecticidal, anti-HIV, antimicrobial, and cytotoxic activities, and are thus of interest for applications in drug design and agriculture. We here report on methods for their discovery and characterization, as well as methods for their quantification in plant tissues and biofluids.
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Tue, 09 Dec 2014, 14:57:11 EST by Susan Allen on behalf of Institute for Molecular Bioscience