Little evidence that FAM65B belongs to the family of phox homology (PX) and bin/amphiphysin/rvs (BAR) domain-containing proteins

Teasdale, Rohan D. and Collins, Brett (2014) Little evidence that FAM65B belongs to the family of phox homology (PX) and bin/amphiphysin/rvs (BAR) domain-containing proteins. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 111 39: E4064-E4064. doi:10.1073/pnas.1412755111


Author Teasdale, Rohan D.
Collins, Brett
Title Little evidence that FAM65B belongs to the family of phox homology (PX) and bin/amphiphysin/rvs (BAR) domain-containing proteins
Journal name PNAS: Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 00278424
1091-6490
Publication date 2014-09-30
Year available 2014
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1073/pnas.1412755111
Open Access Status DOI
Volume 111
Issue 39
Start page E4064
End page E4064
Total pages 1
Place of publication Washington DC United States
Publisher National Academy of Sciences
Language eng
Formatted abstract
Diaz-Horta et al. (1) report the characterization of FAM65B (family with sequence similarity 65, member B), including its mutation in families with recessive hearing loss, its expression and localization in hair cell stereocilia, and the sensorineural hearing loss in a FAM65B knockout zebrafish model. The authors also provide a structural model of the N-terminal 300 amino acids of this 1,068 amino acid protein. This model suggests a homology to the sorting nexin (SNX) family members possessing phox homology (PX) and bin/amphiphysin/rvs (BAR) domains, which promote membrane binding and remodeling, respectively (2, 3). However, our analyses of the FAM65B sequence indicate it …
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Tue, 09 Dec 2014, 14:15:42 EST by Susan Allen on behalf of Institute for Molecular Bioscience