An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer

Balu, Rajkamal, Dutta, Naba K., Choudhury, Namita R., Elvin, Christopher M., Lyons, Russell E., Knott, Robert and Hill, Anita J. (2014) An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer. Acta Biomaterialia, 10 11: 4768-4777. doi:10.1016/j.actbio.2014.07.030


Author Balu, Rajkamal
Dutta, Naba K.
Choudhury, Namita R.
Elvin, Christopher M.
Lyons, Russell E.
Knott, Robert
Hill, Anita J.
Title An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer
Journal name Acta Biomaterialia   Check publisher's open access policy
ISSN 1742-7061
1878-7568
Publication date 2014-11
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.actbio.2014.07.030
Open Access Status
Volume 10
Issue 11
Start page 4768
End page 4777
Total pages 10
Place of publication Amsterdam Netherlands
Publisher Elsevier BV
Collection year 2015
Language eng
Formatted abstract
Engineered protein polymers that display responsiveness to multiple stimuli are emerging as a promising class of soft material with unprecedented functionality. The remarkable advancement in genetic engineering and biosynthesis has created the opportunity for precise control over the amino acid sequence, size, structure and resulting functions of such biomimetic proteins. Herein, we describe the multi-stimuli-responsive characteristics of a resilin-mimetic protein, An16-resilin (An16), derived from the consensus sequence of resilin gene in the mosquito Anopheles gambiae. We demonstrate that An16 is an intrinsically disordered protein that displays unusual dual-phase thermal transition behavior along with responsiveness to pH, ion, light and humidity. Identifying the molecular mechanisms that allow An16 to sense and switch in response to varying environments furthers the ability to design intelligent biomacromolecules.
Keyword An16-resilin
Biomimetic protein
Intrinsically disordered protein (IDP)
Multi-stimuli responsiveness
Self-assembly
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Veterinary Science Publications
 
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