Controlling mechanisms in directional growth of aggregated archaeal cells

Milkevych, Viktor and Batstone, Damien J. (2014) Controlling mechanisms in directional growth of aggregated archaeal cells. Soft Matter, 10 48: 9615-9625. doi:10.1039/c4sm01870b


Author Milkevych, Viktor
Batstone, Damien J.
Title Controlling mechanisms in directional growth of aggregated archaeal cells
Journal name Soft Matter   Check publisher's open access policy
ISSN 1744-6848
1744-683X
Publication date 2014-12-28
Year available 2014
Sub-type Article (original research)
DOI 10.1039/c4sm01870b
Open Access Status Not Open Access
Volume 10
Issue 48
Start page 9615
End page 9625
Total pages 11
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2015
Language eng
Formatted abstract
Members of the family Methanosarcinaceae are important archaeal representatives due to their broad functionality, ubiquitous presence, and functionality in harsh environments. A key characteristic is their multicellular (packet) morphology represented by aggregates of spatially confined cells. This morphology is driven by directed growth of cells in confinement with sequential variation in growth direction. To further understand why spatially confined Methanosarcina cells (and in general, confined prokaryotes) change their direction of growth during consecutive growth-division stages, and how a particular cell senses its wall topology and responds to changes on it a theoretical model for stress dependent growth of aggregated archaeal cells was developed. The model utilizes a confined elastic shell representation of aggregated archaeal cell and is derived based on a work-energy principle. The growth law takes into account the fine structure of archaeal cell wall, polymeric nature of methanochondroitin layer, molecular–biochemical processes and is based on thermodynamic laws. The developed model has been applied to three typical configurations of aggregated cell in 3D. The developed model predicted a geometry response with delayed growth of aggregated archaeal cells explained from mechanistic principles, as well as continuous changes in direction of growth during the consecutive growth-division stages. This means that cell wall topology sensing and growth anisotropy can be predicted using simple cellular mechanisms without the need for dedicated cellular machinery.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Advanced Water Management Centre Publications
 
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