Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis

Pender, Michael P., Csurhes, Peter A., Pfluger, Casey M. M. and Burrows, Scott R. (2014) Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis. Multiple Sclerosis Journal, 20 14: 1825-1832. doi:10.1177/1352458514536252


Author Pender, Michael P.
Csurhes, Peter A.
Pfluger, Casey M. M.
Burrows, Scott R.
Title Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis
Journal name Multiple Sclerosis Journal   Check publisher's open access policy
ISSN 1352-4585
1477-0970
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1177/1352458514536252
Open Access Status
Volume 20
Issue 14
Start page 1825
End page 1832
Total pages 8
Place of publication London, United Kingdom
Publisher Sage Publications
Collection year 2015
Language eng
Formatted abstract
Background: Patients with multiple sclerosis (MS) have a deficiency of circulating CD8+ T cells, which might impair control of Epstein–Barr virus (EBV) and predispose to MS by allowing EBV-infected autoreactive B cells to accumulate in the central nervous system. Based on the expression of CD45RA and CD62L, CD4+ T cells and CD8+ T cells can be subdivided into four subsets with distinct homing and functional properties, namely: naïve, central memory, effector memory (EM) and effector memory re-expressing CD45RA (EMRA) cells.

Objective: Our aim was to determine which memory subsets are involved in the CD8+ T cell deficiency and how these relate to clinical course.

Methods: We used flow cytometry to analyze the memory phenotypes of T cells in the blood of 118 MS patients and 112 healthy subjects.

Results: MS patients had a decreased frequency of EM (CD45RA–CD62L–) and EMRA (CD45RA+CD62L–) CD8+ T cells, which was present at the onset of disease and persisted throughout the clinical course. The frequencies of CD4+ EM and EMRA T cells were normal.

Conclusion: Deficiency of effector memory CD8+ T cells is an early and persistent feature of MS and might underlie the impaired CD8+ T cell control of EBV.
Keyword Multiple sclerosis
Epstein Barr virus
Immunological memory
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Created: Wed, 03 Dec 2014, 14:51:10 EST by Roheen Gill on behalf of UQ Centre for Clinical Research