Effect of caffeine on exercise capacity and function in prostate cancer survivors

Cornish, Rahchell S., Bolam, Kate A. and Skinner, Tina (2015) Effect of caffeine on exercise capacity and function in prostate cancer survivors. Medicine and Science in Sports and Exercise, 47 3: 468-475. doi:10.1249/MSS.0000000000000429

Author Cornish, Rahchell S.
Bolam, Kate A.
Skinner, Tina
Title Effect of caffeine on exercise capacity and function in prostate cancer survivors
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 0195-9131
Publication date 2015-03
Sub-type Article (original research)
DOI 10.1249/MSS.0000000000000429
Open Access Status
Volume 47
Issue 3
Start page 468
End page 475
Total pages 28
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Collection year 2016
Language eng
Formatted abstract
Purpose: This study aimed to examine the acute effect of caffeine on exercise capacity, exercise-related fatigue, and functional performance in prostate cancer survivors.

Methods: In this randomized, placebo-controlled, double-blind crossover study, 30 prostate cancer survivors (age, 70.3 ± 7.7 yr; body mass, 80.5 ± 13.0 kg; mean ± SD) consumed 6.04 ± 0.16 mg·kg-1 of anhydrous caffeine or a placebo 1 h before completing a battery of exercise capacity and functional performance tests. Testing sessions were separated by 3–4 wk. Immediate fatigue and perceived exertion were measured directly pre- and postexercise at both testing sessions.

Results: Caffeine increased exercise capacity by 7.93 s (+3.0%; P = 0.010); however, postexercise fatigue and perception of exertion were comparable with the placebo session (P = 0.632 and P = 0.902, respectively). Increases in isometric grip strength trended toward significance in both dominant (+2.9%; P = 0.053) and nondominant (+2.1%; P = 0.061) hands in the caffeine trial compared with placebo. Caffeine ingestion did not result in improvements in performance for any of the remaining functional measures, including the timed up-and-go test, repeated chair stands, 6-m fast walk, and 6-m backward tandem walk. Systolic blood pressure and HR were significantly increased (P = 0.006 and P = 0.040, respectively) upon completion of the testing battery when compared with placebo.

Conclusions: Consumption of caffeine 1 h before exercise induced improvements in exercise capacity and muscular strength in prostate cancer survivors. However, there was no change in exercise-related fatigue when compared with placebo despite reduction in timed performance of the 400-m walk. Caffeine seems to enhance exercise tolerance through improved performance with no subsequent increase in fatigue or perception of exertion and may be an appropriate strategy to promote exercise participation in prostate cancer survivors.
Keyword Perception of effort
Older adults
Performance-enhancing substances
Ergogenic aid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
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Created: Tue, 02 Dec 2014, 16:27:02 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences