Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action

Alam, M. Ashraful, Subhan, Nusrat, Rahman, M. Mahbubur, Uddin, Shaikh J., Reza, Hasan M. and Sarker, Satyajit D. (2014) Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Advances in Nutrition, 5 4: 404-417. doi:10.3945/an.113.005603


Author Alam, M. Ashraful
Subhan, Nusrat
Rahman, M. Mahbubur
Uddin, Shaikh J.
Reza, Hasan M.
Sarker, Satyajit D.
Title Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action
Journal name Advances in Nutrition   Check publisher's open access policy
ISSN 2161-8313
2156-5376
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3945/an.113.005603
Open Access Status
Volume 5
Issue 4
Start page 404
End page 417
Total pages 14
Place of publication Bethesda, MD United States
Publisher American Society for Nutrition
Collection year 2015
Language eng
Formatted abstract
Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome. A number of molecular mechanisms underlying its beneficial activities have been elucidated. However, their effect on obesity and metabolic disorder remains to be fully established. Moreover, the therapeutic uses of these flavonoids are significantly limited by the lack of adequate clinical evidence. This review aims to explore the biologic activities of these compounds, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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