Multiple primary cancers associated with merkel cell carcinoma in Queensland, Australia, 1982-2011

Youlden, Danny R., Youl, Philippa H., Soyer, H. Peter, Fritschi, Lin and Baade, Peter D. (2014) Multiple primary cancers associated with merkel cell carcinoma in Queensland, Australia, 1982-2011. Journal of Investigative Dermatology, 134 12: 2883-2889. doi:10.1038/jid.2014.266


Author Youlden, Danny R.
Youl, Philippa H.
Soyer, H. Peter
Fritschi, Lin
Baade, Peter D.
Title Multiple primary cancers associated with merkel cell carcinoma in Queensland, Australia, 1982-2011
Journal name Journal of Investigative Dermatology   Check publisher's open access policy
ISSN 1523-1747
0022-202X
Publication date 2014-12-13
Year available 2014
Sub-type Article (original research)
DOI 10.1038/jid.2014.266
Open Access Status
Volume 134
Issue 12
Start page 2883
End page 2889
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract The relatively high incidence of Merkel cell carcinoma (MCC) in Queensland provides a valuable opportunity to examine links with other cancers. A retrospective cohort study was performed using data from the Queensland Cancer Registry. Standardized incidence ratios (SIRs) were used to approximate the relative risk of being diagnosed with another primary cancer either following or prior to MCC. Patients with an eligible first primary MCC (n=787) had more than double the expected number of subsequent primary cancers (SIR=2.19, 95% confidence interval (CI)=1.84–2.60; P<0.001). Conversely, people who were initially diagnosed with cancers other than MCC were about two and a half times more likely to have a subsequent primary MCC (n=244) compared with the general population (SIR=2.69, 95% CI=2.36–3.05; P<0.001). Significantly increased bi-directional relative risks were found for melanoma, lip cancer, head and neck cancer, lung cancer, myelodysplastic diseases, and cancer with unknown primary site. In addition, risks were elevated for female breast cancer and kidney cancer following a first primary MCC, and for subsequent MCCs following first primary colorectal cancer, prostate cancer, non-Hodgkin lymphoma, or lymphoid leukemia. These results suggest that several shared pathways are likely for MCC and other cancers, including immunosuppression, UV radiation, and genetics.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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