Functionally connected brain regions in the network activated during capsaicin inhalation

Farrell, Michael J., Koch, Saskia, Ando, Ayaka, Cole, Leonie J., Egan, Gary F. and Mazzone, Stuart B. (2014) Functionally connected brain regions in the network activated during capsaicin inhalation. Human Brain Mapping, 35 11: 5341-5355. doi:10.1002/hbm.22554


Author Farrell, Michael J.
Koch, Saskia
Ando, Ayaka
Cole, Leonie J.
Egan, Gary F.
Mazzone, Stuart B.
Title Functionally connected brain regions in the network activated during capsaicin inhalation
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1097-0193
1065-9471
Publication date 2014-11-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/hbm.22554
Open Access Status
Volume 35
Issue 11
Start page 5341
End page 5355
Total pages 15
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2015
Language eng
Formatted abstract
Coughing and the urge-to-cough are important mechanisms that protect the patency of the airways, and are coordinated by the brain. Inhaling a noxious substance leads to a widely distributed network of responses in the brain that are likely to reflect multiple functional processes requisite for perceiving, appraising, and behaviorally responding to airway challenge. The broader brain network responding to airway challenge likely contains subnetworks that are involved in the component functions required for coordinated protective behaviors. Functional connectivity analyses were used to determine whether brain responses to airway challenge could be differentiated regionally during inhalation of the tussive substance capsaicin. Seed regions were defined according to outcomes of previous activation studies that identified regional brain responses consistent with cough suppression, stimulus intensity coding, and perception of urge-to-cough. The subnetworks during continuous inhalation of capsaicin recapitulated the distributed regions previously implicated in discrete functional components of airway challenge. The outcomes of this study highlight the central representation of airways defence as a distributed network.
Keyword Brain mapping
Cough
Sensation
Magnetic resonance imaging
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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