A neonatal blueprint for cardiac regeneration

Porrello, Enzo R. and Olson, Eric N. (2014) A neonatal blueprint for cardiac regeneration. Stem Cell Research, 13 3: 556-570. doi:10.1016/j.scr.2014.06.003

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Author Porrello, Enzo R.
Olson, Eric N.
Title A neonatal blueprint for cardiac regeneration
Journal name Stem Cell Research   Check publisher's open access policy
ISSN 1873-5061
Publication date 2014-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.scr.2014.06.003
Open Access Status DOI
Volume 13
Issue 3
Start page 556
End page 570
Total pages 15
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Recent studies have established the importance of several evolutionarily conserved mechanisms for heart regeneration in lower vertebrates and neonatal mammals including induction of cardiomyocyte proliferation, epicardial cell activation, angiogenesis, extracellular matrix deposition and immune cell infiltration. In this review, we provide an up-to-date account of the molecular and cellular basis for cardiac regeneration in lower vertebrates and neonatal mammals. The historical context for these recent findings and their ramifications for the future development of cardiac regenerative therapies are also discussed.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 02 Dec 2014, 00:37:40 EST by System User on behalf of School of Biomedical Sciences