Diversity and variability of NOD-like receptors in fungi

Dyrka, Witold, Lamacchia, Marina, Durrens, Pascal, Kobe, Bostjan, Daskalov, Asen, Paoletti, Matthieu, Sherman, David J. and Saupe, Sven J. (2014) Diversity and variability of NOD-like receptors in fungi. Genome Biology and Evolution, 6 12: 3137-3158. doi:10.1093/gbe/evu251

Author Dyrka, Witold
Lamacchia, Marina
Durrens, Pascal
Kobe, Bostjan
Daskalov, Asen
Paoletti, Matthieu
Sherman, David J.
Saupe, Sven J.
Title Diversity and variability of NOD-like receptors in fungi
Journal name Genome Biology and Evolution   Check publisher's open access policy
ISSN 1759-6653
Publication date 2014-11-13
Year available 2014
Sub-type Article (original research)
DOI 10.1093/gbe/evu251
Open Access Status DOI
Volume 6
Issue 12
Start page 3137
End page 3158
Total pages 22
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2015
Language eng
Abstract NOD-like receptors (NLRs) are intracellular receptors that control innate immunity and other biotic interactions in animals and plants. NLRs have been characterized in plant and animal lineages, but in fungi, this gene family has not been systematically described. There is however previous indications of the involvement of NLR-like genes in non-self recognition and programmed cell death in fungi. We have analyzed 198 fungal genomes for the presence of NLRs and have annotated a total of 5616 NLR candidates. We describe their phylogenetic distribution, domain organization and evolution. Fungal NLRs are characterized by a great diversity of domain organizations, suggesting frequently occurring combinatorial assortments of different effector, NOD and repeat domains. The repeat domains are of the WD, ANK and TPR type; no LRR motifs were found. As previously documented for WD-repeat domains of fungal NLRs, TPR and ANK repeats evolve under positive selection and show highly conserved repeats and repeat length polymorphism, suggesting the possibility of concerted evolution of these repeats. We identify novel effector domains not previously found associated with NLRs, while others are related to effector domains of plant or animals NLRs. In particular, we show that the HET domain found in fungal NLRs may be related to TIR domains found in animal and plant immune receptors. This description of fungal NLR repertoires reveals both similarities and differences with plant and animals NLR collections, highlights the importance of domain re-assortment and repeat evolution and provides a novel entry point to explore the evolution of NLRs in eukaryotes.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 13 November 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
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Created: Fri, 21 Nov 2014, 09:28:33 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences