Molecular psychiatry of zebrafish

Stewart, A. M ., Ullmann, J. F. P., Norton, W. H. J., Parker, M. O., Brennan, C. H., Gerlai, R. and Kalueff, A. V. (2014) Molecular psychiatry of zebrafish. Molecular Psychiatry, 20 1: 1-16. doi:10.1038/mp.2014.128

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Author Stewart, A. M .
Ullmann, J. F. P.
Norton, W. H. J.
Parker, M. O.
Brennan, C. H.
Gerlai, R.
Kalueff, A. V.
Title Molecular psychiatry of zebrafish
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
Publication date 2014-10-28
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/mp.2014.128
Open Access Status
Volume 20
Issue 1
Start page 1
End page 16
Total pages 16
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Formatted abstract
Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Advance online publication 28 October 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
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Created: Thu, 20 Nov 2014, 09:57:04 EST by Shona Osborne on behalf of Centre for Advanced Imaging