Behavioural and neural changes after a “choice” therapy for naming deficits in aphasia: preliminary findings

Leonard, Carol, Laird, Laura, Burianova, Hana, Graham, Simon, Grady, Cheryl, Simic, Tijana and Rochon, Elizabeth (2014) Behavioural and neural changes after a “choice” therapy for naming deficits in aphasia: preliminary findings. Aphasiology, 29 4: 506-525. doi:10.1080/02687038.2014.971099

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Author Leonard, Carol
Laird, Laura
Burianova, Hana
Graham, Simon
Grady, Cheryl
Simic, Tijana
Rochon, Elizabeth
Title Behavioural and neural changes after a “choice” therapy for naming deficits in aphasia: preliminary findings
Journal name Aphasiology   Check publisher's open access policy
ISSN 0268-7038
1464-5041
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1080/02687038.2014.971099
Open Access Status File (Author Post-print)
Volume 29
Issue 4
Start page 506
End page 525
Total pages 20
Place of publication Abingdon, Oxon, United Kingdom
Publisher Routledge
Collection year 2015
Language eng
Formatted abstract
Background: Anomia, difficulty producing words, is a pervasive symptom of many individuals with aphasia. We have developed a treatment for naming deficits—the Phonological Components Analysis (PCA) protocol—that has proven efficacious in improving word-finding abilities for individuals with post-stroke aphasia.

Aims: The aim of this investigation is to present preliminary findings exploring the potential influence of choice—that is the active engagement of a participant in therapy—on our PCA treatment.

Methods & Procedures: Five individuals with aphasia were treated in one of two conditions—Choice or No Choice. Potential changes in neural activation as a function of the treatment were also investigated. Two individuals (one from each condition) underwent functional MRI (fMRI) pre- and post-therapy.

Outcomes & Results: All the individuals demonstrated a significant treatment effect immediately post-treatment and at a 4-week follow-up and four of the five participants at an 8-week follow-up. Three also demonstrated generalisation to untrained items. Unfortunately, no clear-cut patterns emerged to allow us to make claims about the influence of choice, per se, on the behavioural manifestations of improved naming. Interestingly, the participant from the Choice condition showed neural activation changes post-treatment in frontal and parietal regions that were not evident for the participant in the No Choice condition. Moreover, these changes were accompanied by a larger treatment effect for that individual and generalisation to a novel naming task.

Conclusion: The efficacy of PCA treatment for naming deficits is further supported. In addition, the neuroimaging data suggest the possibility that active engagement of an individual in his/her therapy (in this case choosing phonological attributes of a target word) may exercise executive functions important for success in treating anomia. Also, continued exploration of task factors that may promote even better treatment effects using this protocol is warranted, as is continued investigation of the neural underpinnings associated with treatment effects.
Keyword Stroke
Aphasia
Anomia
Rehabilitation
Neuroimaging
Neuroplasticity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Centre for Advanced Imaging Publications
 
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Created: Thu, 20 Nov 2014, 09:39:45 EST by Shona Osborne on behalf of Centre for Advanced Imaging