The elucidation of the importance of various factors influencing the optical activity of simple amino acid metal complexes was attempted in this project with a view to a greater understanding of more complex systems of biological importance.
For a series of unidentate and chelated tetragonal (α-amino acid)amminecobalt(III) complexes it has been possible to determine the nature of the individual optically active ligand field transitions and their signs of Cotton effect ascertained for α-amino acids of a given configuration. This study has shown how cobalt(III) complexes of the type under discussion may be used to objectively determine the absolute configuration of a new optically active α-amino acid.
The sources of dissymmetry present in these complexes and the manner in which they impose rotational strength onto the metal-ion chromophore is discussed and a summary and unifying reinterpretation of the optical activity properties of various related tetragonal(α-amino carboxylate) metal complexes is given.
Publications resulting from work described in this thesis are as follows:
(i) "Absolute Configurations of Amino-acids and other α-substituted carboxylates", Hawkins, C.J., and Lawson, P.J., (1968) Chem. Commun., 177 DOI:10.1039/C19680000177
(ii) "Circular Dichroism Spectra of Amino Acid Complexes: Carboxylatopentamminecobalt(III) Compounds", Hawkins, C.J., and Lawson, P.J., (1969) Submitted for publication. DOI:10.1021/ic50083a002
(iii) "Circular Dichroism Spectra of Amino Acid Complexes. III. Chelated Amino Acid Complexes with the CoN5O Chromophore.", Hawkins, C.J., and Lawson, P.J., (1969) To be submitted for publication.