Factors governing the circular dichroism of amino acid metal complexes

Lawson, Peter John (1969). Factors governing the circular dichroism of amino acid metal complexes PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi:10.14264/uql.2014.369

       
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Author Lawson, Peter John
Thesis Title Factors governing the circular dichroism of amino acid metal complexes
School, Centre or Institute School of Molecular and Microbial Sciences
Institution The University of Queensland
DOI 10.14264/uql.2014.369
Publication date 1969-01-01
Thesis type PhD Thesis
Supervisor C. J. Hawkins
Total pages 136
Language eng
Subjects 0302 Inorganic Chemistry
Formatted abstract
The elucidation of the importance of various factors influencing the optical activity of simple amino acid metal complexes was attempted in this project with a view to a greater understanding of more complex systems of biological importance.

For a series of unidentate and chelated tetragonal (α-amino acid)amminecobalt(III) complexes it has been possible to determine the nature of the individual optically active ligand field transitions and their signs of Cotton effect ascertained for α-amino acids of a given configuration. This study has shown how cobalt(III) complexes of the type under discussion may be used to objectively determine the absolute configuration of a new optically active α-amino acid.

The sources of dissymmetry present in these complexes and the manner in which they impose rotational strength onto the metal-ion chromophore is discussed and a summary and unifying reinterpretation of the optical activity properties of various related tetragonal(α-amino carboxylate) metal complexes is given.

Publications resulting from work described in this thesis are as follows:
(i) "Absolute Configurations of Amino-acids and other α-substituted carboxylates", Hawkins, C.J., and Lawson, P.J., (1968) Chem. Commun., 177 DOI:10.1039/C19680000177
(ii) "Circular Dichroism Spectra of Amino Acid Complexes: Carboxylatopentamminecobalt(III) Compounds", Hawkins, C.J., and Lawson, P.J., (1969) Submitted for publication. DOI:10.1021/ic50083a002
(iii) "Circular Dichroism Spectra of Amino Acid Complexes. III. Chelated Amino Acid Complexes with the CoN5O Chromophore.", Hawkins, C.J., and Lawson, P.J., (1969) To be submitted for publication.
Keyword Amino acids -- Optical properties
Circular dichroism

Document type: Thesis
Collection: UQ Theses (RHD) - UQ staff and students only
 
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