Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza

Gong, Yumei, Zhang, Peijun, Wang, Hongjun, Zhu, Wenge, Sun, Huiling, He, Yunxia, Shao, Qinghong and Blackall, P. J. (2014) Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza. Veterinary Immunology and Immunopathology, 158 1-2: 3-7. doi:10.1016/j.vetimm.2013.01.015


Author Gong, Yumei
Zhang, Peijun
Wang, Hongjun
Zhu, Wenge
Sun, Huiling
He, Yunxia
Shao, Qinghong
Blackall, P. J.
Title Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza
Journal name Veterinary Immunology and Immunopathology   Check publisher's open access policy
ISSN 0165-2427
1873-2534
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.vetimm.2013.01.015
Open Access Status
Volume 158
Issue 1-2
Start page 3
End page 7
Total pages 5
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Collection year 2015
Language eng
Formatted abstract
The safety and efficacy of an inactivated oil-emulsion infectious coryza vaccine containing three Avibacterium paragallinarum isolates (one each of Page serovars A, B, and C) was evaluated. The safety of six batches of the vaccine was confirmed by testing with chickens vaccinated with a single large dose or vaccinated repeatedly with a normal dose. Efficacy tests were carried out on three batches of vaccine using both specific pathogen free (SPF) chickens and conventional chickens. In SPF chickens given a single vaccination at 42 days of age, the protection rate against all three serovars of Av. paragallinarum was at least 80% at 30 days post vaccination. The conventional chickens, which were immunized at 42 and 110 days of age, were challenged at 9 months post the second vaccination and the protection rate was at least 80% for all three serovars. The effect of storage on the vaccine was evaluated in SPF chickens using three batches of vaccine stored at 4-8. °C for 1 year. The protection rate against challenge from all three serovars (single vaccination at 42 days of age and challenge at 30 days post-vaccination) was at least 80%.
Keyword Infectious coryza
Trivalent inactivated vaccine
Safety
Potency
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2015 Collection
 
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Created: Tue, 18 Nov 2014, 09:58:11 EST by Dr Patrick Blackall on behalf of Centre for Animal Science