Evidence synthesis for medical decision making and the appropriate use of quality scores

Doi, Suhail A. R. (2014) Evidence synthesis for medical decision making and the appropriate use of quality scores. Clinical Medicine and Research, 12 1-2: 40-46. doi:10.3121/cmr.2013.1188


Author Doi, Suhail A. R.
Title Evidence synthesis for medical decision making and the appropriate use of quality scores
Journal name Clinical Medicine and Research   Check publisher's open access policy
ISSN 1554-6179
1539-4182
Publication date 2014-09-01
Year available 2014
Sub-type Article (original research)
DOI 10.3121/cmr.2013.1188
Open Access Status DOI
Volume 12
Issue 1-2
Start page 40
End page 46
Total pages 7
Place of publication Marshfield, WI, United States
Publisher Marshfield Clinic
Collection year 2015
Language eng
Abstract Meta-analyses today continue to be run using conventional random-effects models that ignore tangible information from studies such as the quality of the studies involved, despite the expectation that results of better quality studies reflect more valid results. Previous research has suggested that quality scores derived from such quality appraisals are unlikely to be useful in meta-analysis, because they would produce biased estimates of effects that are unlikely to be offset by a variance reduction within the studied models. However, previous discussions took place in the context of such scores viewed in terms of their ability to maximize their association with both the magnitude and direction of bias. In this review, another look is taken at this concept, this time asserting that probabilistic bias quantification is not possible or even required of quality scores when used in meta-analysis for redistribution of weights. The use of such a model is contrasted with the conventional random effects model of meta-analysis to demonstrate why the latter is inadequate in the face of a properly specified quality score weighting method.
Keyword Bias
Medical decision making
Meta-analysis
Quality scores
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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Created: Mon, 17 Nov 2014, 17:57:53 EST by System User on behalf of School of Public Health