Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population

Okolicsanyi, Rachel K., Buffiere, Anne, Jacinto, Jose M. E., Chacon-Cortes, Diego, Chambers, Suzanne K., Youl, Philippa H., Haupt, Larisa M. and Griffiths, Lyn R. (2014) Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population. Tumor Biology, 36 3: 1731-1738. doi:10.1007/s13277-014-2774-3


Author Okolicsanyi, Rachel K.
Buffiere, Anne
Jacinto, Jose M. E.
Chacon-Cortes, Diego
Chambers, Suzanne K.
Youl, Philippa H.
Haupt, Larisa M.
Griffiths, Lyn R.
Title Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population
Journal name Tumor Biology   Check publisher's open access policy
ISSN 1423-0380
1010-4283
Publication date 2014-11-01
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s13277-014-2774-3
Open Access Status
Volume 36
Issue 3
Start page 1731
End page 1738
Total pages 8
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Collection year 2015
Language eng
Formatted abstract
Breast cancer is a common disease in both developing and developed countries with early identification and treatment improving prognosis and survival. Heparan sulfate proteoglycans (HSPGs) are key components of the extracellular matrix (ECM) that mediate cell adhesion, motility, proliferation, invasion and cell signalling. Members of the syndecan family of HSPGs have been identified to be involved in breast cancer progression through their varied interactions with a number of growth factors, ligands and receptors. Specifically, high expression levels of syndecan-1 (SDC1) have been demonstrated in more invasive breast tumours while elevated syndecan-4 (SDC4) levels have been identified to correspond with improved prognosis. With genetic changes in the syndecans and their association with breast cancers plausible, we examined two single nucleotide polymorphisms in SDC1 (rs1131351) and SDC4 (rs67068737) within an Australian Caucasian breast cancer case/control population. No association was found with SDC4 and breast cancer in our population. However, a significant association between SDC1 and breast cancer was identified in both our case/control population and in a replication cohort. When both populations were combined for analysis, this association became more significant (genotype, p = 0.0003; allele, p = 0.0001). This data suggests an increased risk of developing breast cancer associated with the presence of the C allele of the SDC1 rs1131351 single nucleotide polymorphism (SNP) and may provide a marker toward early breast cancer detection.
Keyword HSPG
Syndecan
Breast cancer
SNP
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 1 November 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
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