Historical intake and elimination of polychlorinated biphenyls and organochlorine pesticides by the Australian population reconstructed from biomonitoring data

Bu, Qingwei, MacLeod, Matthew, Wong, Fiona, Toms, Leisa-Maree L., Mueller, Jochen F. and Yu, Gang (2015) Historical intake and elimination of polychlorinated biphenyls and organochlorine pesticides by the Australian population reconstructed from biomonitoring data. Environment International, 74 82-88. doi:10.1016/j.envint.2014.09.014


Author Bu, Qingwei
MacLeod, Matthew
Wong, Fiona
Toms, Leisa-Maree L.
Mueller, Jochen F.
Yu, Gang
Title Historical intake and elimination of polychlorinated biphenyls and organochlorine pesticides by the Australian population reconstructed from biomonitoring data
Journal name Environment International   Check publisher's open access policy
ISSN 1873-6750
0160-4120
Publication date 2015-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.envint.2014.09.014
Open Access Status DOI
Volume 74
Start page 82
End page 88
Total pages 7
Place of publication Kidlington, Oxford United Kingdom
Publisher Pergamon Press [Elsevier]
Collection year 2015
Language eng
Abstract Quantifying the competing rates of intake and elimination of persistent organic pollutants (POPs) in the human body is necessary to understand the levels and trends of POPs at a population level. In this paper we reconstruct the historical intake and elimination of ten polychlorinated biphenyls (PCBs) and five organochlorine pesticides (OCPs) from Australian biomonitoring data by fitting a population-level pharmacokinetic (PK) model. Our analysis exploits two sets of cross-sectional biomonitoring data for PCBs and OCPs in pooled blood serum samples from the Australian population that were collected in 2003 and 2009. The modeled adult reference intakes in 1975 for PCB congeners ranged from 0.89 to 24.5 ng/kg bw/day, lower than the daily intakes of OCPs ranging from 73 to 970 ng/kg bw/day. Modeled intake rates are declining with half-times from 1.1 to 1.3 years for PCB congeners and 0.83 to 0.97 years for OCPs. The shortest modeled intrinsic human elimination half-life among the compounds studied here is 6.4 years for hexachlorobenzene, and the longest is 30 years for PCB-74. Our results indicate that it is feasible to reconstruct intakes and to estimate intrinsic human elimination half-lives using the population-level PK model and biomonitoring data only. Our modeled intrinsic human elimination half-lives are in good agreement with values from a similar study carried out for the population of the United Kingdom, and are generally longer than reported values from other industrialized countries in the Northern Hemisphere.
Keyword PCBs
OCPs
Modeling
Pharmacokinetics
Elimination
Intake
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 20 Oct 2015

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
National Research Centre for Environmental Toxicology Publications
 
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