Sex-and age-related differences in the chronic pressure-natriuresis relationship: Role of the angiotensin type 2 receptor

Mirabito, Katrina M., Hilliard, Lucinda M., Kett, Michelle M., Brown, Russell D., Booth, Sean C., Widdop, Robert E., Moritz, Karen M., Evans, Roger G. and Denton, Kate M. (2014) Sex-and age-related differences in the chronic pressure-natriuresis relationship: Role of the angiotensin type 2 receptor. American Journal of Physiology: Renal Physiology, 307 8: F901-F907. doi:10.1152/ajprenal.00288.2014


Author Mirabito, Katrina M.
Hilliard, Lucinda M.
Kett, Michelle M.
Brown, Russell D.
Booth, Sean C.
Widdop, Robert E.
Moritz, Karen M.
Evans, Roger G.
Denton, Kate M.
Title Sex-and age-related differences in the chronic pressure-natriuresis relationship: Role of the angiotensin type 2 receptor
Journal name American Journal of Physiology: Renal Physiology   Check publisher's open access policy
ISSN 1522-1466
Publication date 2014-10-15
Year available 2014
Sub-type Article (original research)
DOI 10.1152/ajprenal.00288.2014
Open Access Status
Volume 307
Issue 8
Start page F901
End page F907
Total pages 7
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Collection year 2015
Language eng
Abstract Sex hormones regulate the renin-angiotensin system. For example, estrogen enhances expression of the angiotensin type 2 receptor. We hypothesized that activation of the angiotensin type 2 receptor shifts the chronic pressure-natriuresis relationship leftward in females compared with males and that this effect is lost with age. Mean arterial pressure was measured by radiotelemetry in adult (4 mo old) and aged (14 mo old) wild-type and angiotensin type 2 receptor knockout male and female mice. Chronic pressure-natriuresis curves were constructed while mice were maintained on a normal-salt (0.26%) diet and following 6 days of high salt (5.0%) diet. Mean arterial pressure was lower in adult wild-type females than males (88 ± 1 and 97 ± 1 mmHg, respectively), a difference that was maintained with age, but was absent in adult knockout mice. In wild-type females, the chronic pressure-natriuresis relationship was shifted leftward compared with knockout females, an effect that was lost with age. In males, the chronic pressure-natriuresis relationship was not influenced by angiotensin type 2 receptor deficiency. Compared with age-matched females, the chronic pressure-natriuresis relationships in male mice were shifted rightward. Renal expression of the angiotensin type 2 receptor was fourfold greater in adult wild-type females than males. With age, the angiotensin type 2 receptor-to-angiotensin type 1 receptor balance was reduced in females. Conversely, in males, angiotensin receptor expression did not vary significantly with age. In conclusion, the angiotensin type 2 receptor modulates the chronic pressure-natriuresis relationship in an age- and sex-dependent manner.
Keyword Angiotensin type 2 receptor
Sex differences
Hypertension
Aging
Natriuresis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 16 Nov 2014, 01:18:10 EST by System User on behalf of School of Biomedical Sciences