Regulation Mechanisms in Mixed and Pure Culture Microbial Fermentation

Hoelzle, Robert D., Virdis, Bernardino and Batstone, Damien J. (2014) Regulation Mechanisms in Mixed and Pure Culture Microbial Fermentation. Biotechnology and Bioengineering, 111 11: 2139-2154. doi:10.1002/bit.25321

Author Hoelzle, Robert D.
Virdis, Bernardino
Batstone, Damien J.
Title Regulation Mechanisms in Mixed and Pure Culture Microbial Fermentation
Journal name Biotechnology and Bioengineering   Check publisher's open access policy
ISSN 0006-3592
Publication date 2014-11
Year available 2014
Sub-type Article (original research)
DOI 10.1002/bit.25321
Volume 111
Issue 11
Start page 2139
End page 2154
Total pages 16
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons
Collection year 2015
Language eng
Formatted abstract
Mixed-culture fermentation is a key central process to enable next generation biofuels and biocommodity production due to economic and process advantages over application of pure cultures. However, a key limitation to the application of mixed-culture fermentation is predicting culture product response, related to metabolic regulation mechanisms. This is also a limitation in pure culture bacterial fermentation. This review evaluates recent literature in both pure and mixed culture studies with a focus on understanding how regulation and signaling mechanisms interact with metabolic routes and activity. In particular, we focus on how microorganisms balance electron sinking while maximizing catabolic energy generation. Analysis of these mechanisms and their effect on metabolism dynamics is absent in current models of mixed-culture fermentation. This limits process prediction and control, which in turn limits industrial application of mixed-culture fermentation. A key mechanism appears to be the role of internal electron mediating cofactors, and related regulatory signaling. This may determine direction of electrons towards either hydrogen or reduced organics as end-products and may form the basis for future mechanistic models.
Keyword Mixed microbial population
Electron mediation
Fermentation products
Waste Treatment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Advanced Water Management Centre Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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