The survival outcome and patterns of failure in node positive endometrial cancer patients treated with surgery and adjuvant radiotherapy with curative intent

Rajasooriyar, Chrishanthi, Bernshaw, David, Kondalsamy-Chennakesavan, Srinivas, Mileshkin, Linda and Narayan, Kailash (2014) The survival outcome and patterns of failure in node positive endometrial cancer patients treated with surgery and adjuvant radiotherapy with curative intent. Journal of Gynecologic Oncology, 25 4: 313-319. doi:10.3802/jgo.2014.25.4.313


Author Rajasooriyar, Chrishanthi
Bernshaw, David
Kondalsamy-Chennakesavan, Srinivas
Mileshkin, Linda
Narayan, Kailash
Title The survival outcome and patterns of failure in node positive endometrial cancer patients treated with surgery and adjuvant radiotherapy with curative intent
Journal name Journal of Gynecologic Oncology   Check publisher's open access policy
ISSN 2005-0399
2005-0380
Publication date 2014-10-01
Year available 2014
Sub-type Article (original research)
DOI 10.3802/jgo.2014.25.4.313
Open Access Status
Volume 25
Issue 4
Start page 313
End page 319
Total pages 7
Place of publication Gangnam-gu, Seoul, Republic of Korea
Publisher Korean Society of Gynecologic Oncology
Collection year 2015
Language eng
Formatted abstract
Objective

The purpose of this study was to evaluate the patterns of failure, overall survival (OS), disease-free survival (DFS) and factors influencing outcome in endometrial cancer patients who presented with metastatic lymph nodes and were treated with curative intent.

Methods

One hundred and twenty-six patients treated between January 1996 to December 2008 with surgery and adjuvant radiotherapy were identified from our service's prospective database. Radiotherapy consisted of 45 Gy in 1.8 Gy fractions to the whole pelvis. The involved nodal sites were boosted to a total dose of 50.4 to 54 Gy.

Results

The 5-year OS rate was 61% and the 5-year DFS rate was 59%. Grade 3 endometrioid, serous, and clear cell histologies and involvement of upper para-aortic nodes had lower OS and DFS. The number of positive nodes did not influence survival. Among the histological groups, serous histology had the worst survival. Among the 54 patients relapsed, only three (6%) failed exclusively in the pelvis and the rest of the 94% failed in extrapelvic nodal or distant sites. Patients with grade 3 endometrioid, serous and clear cell histologies did not influence pelvic failure but had significant extrapelvic failures (p<0.001).

Conclusion

Majority of node positive endometrial cancer patients fail at extrapelvic sites. The most important factors influencing survival and extrapelvic failure are grade 3 endometrioid, clear cell and serous histologies and involvement of upper para-aortic nodes.
Keyword Endometrial neoplasms
Lymph nodes
Prospective studies
Radiotherapy
Survival rate
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 16 Nov 2014, 00:30:27 EST by System User on behalf of Rural Clinical School