Beyond the Single SNP: Emerging Developments in Mendelian Randomization in the “Omics” Era

Brion, Marie-Jo A., Benyamin, Beben, Visscher, Peter M. and Smith, George Davey (2014) Beyond the Single SNP: Emerging Developments in Mendelian Randomization in the “Omics” Era. Current Epidemiology Reports, 1 4: 228-236. doi:10.1007/s40471-014-0024-2

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Author Brion, Marie-Jo A.
Benyamin, Beben
Visscher, Peter M.
Smith, George Davey
Title Beyond the Single SNP: Emerging Developments in Mendelian Randomization in the “Omics” Era
Journal name Current Epidemiology Reports   Check publisher's open access policy
ISSN 2196-2995
Publication date 2014-09-25
Sub-type Article (original research)
DOI 10.1007/s40471-014-0024-2
Open Access Status
Volume 1
Issue 4
Start page 228
End page 236
Total pages 9
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2015
Language eng
Abstract Mendelian randomization (MR) is an innovative epidemiological approach that uses genetic variants as proxies for environmental exposures to provide unbiased estimates of the causal effect of a risk factor on disease. The explosion in availability of high-throughput biological data has resulted in increasing numbers of MR studies, novel extensions to the traditional single-SNP MR approach, and the potential to incorporate new-generation biological “omics” data (such as genome-wide genotype data, epigenetics, and metabolomic data). In this review, we discuss these new developments, ranging from the application of multiple genetic markers and the use of summary statistic data to MR approaches in the “omics” age. Progress in “omics” technologies has been touted as a means to revolutionize epidemiology, and the incorporation of “omics” data into MR to infer causality of potentially large numbers of novel biological markers represents one avenue in how this may be realized.
Keyword Causality
DNA sequence
Disease etiology
Instrumental variable
Mendelian randomization
Omics risk factors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Created: Thu, 13 Nov 2014, 20:39:08 EST by Beben Benyamin on behalf of Queensland Brain Institute