Translational biology of osteosarcoma

Kansara, Maya, Teng, Michele W., Smyth, Mark J. and Thomas, David M. (2014) Translational biology of osteosarcoma. Nature Reviews Cancer, 14 11: 722-735. doi:10.1038/nrc3838


Author Kansara, Maya
Teng, Michele W.
Smyth, Mark J.
Thomas, David M.
Title Translational biology of osteosarcoma
Journal name Nature Reviews Cancer   Check publisher's open access policy
ISSN 1474-1768
1474-175X
Publication date 2014-10-27
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrc3838
Open Access Status
Volume 14
Issue 11
Start page 722
End page 735
Total pages 14
Place of publication Londond, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing. Bone has a highly specialized immune environment and many immune signalling pathways are important in bone homeostasis. The success of the innate immune stimulant mifamurtide in the adjuvant treatment of non-metastatic osteosarcoma suggests that newer immune-based treatments, such as immune checkpoint inhibitors, may substantially improve disease outcome.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
 
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