The contribution of genetic variants to disease depends on the ruler

Witte, John S., Visscher, Peter M. and Wray, Naomi R. (2014) The contribution of genetic variants to disease depends on the ruler. Nature Reviews Genetics, 15 11: 765-776. doi:10.1038/nrg3786

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ344832_OA.pdf Full text (open access) application/pdf 649.49KB 11

Author Witte, John S.
Visscher, Peter M.
Wray, Naomi R.
Title The contribution of genetic variants to disease depends on the ruler
Journal name Nature Reviews Genetics   Check publisher's open access policy
ISSN 1471-0056
Publication date 2014-11-25
Year available 2014
Sub-type Article (original research)
DOI 10.1038/nrg3786
Open Access Status File (Author Post-print)
Volume 15
Issue 11
Start page 765
End page 776
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Formatted abstract
Key points• Introduction• Measures of genetic impact for individual risk loci• Comparison of measures for single variants• Contribution of multiple risk loci to disease• Application to complex diseases• PAF: a problematic measure• Measures depend on the overall disease risk• Focus on the mean or the variance?• Extensions and additional measures• Conclusions and future perspectives• References• Acknowledgements• Author information• Supplementary information• Related links• Glossary
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
UQ Diamantina Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 11 Nov 2014, 05:15:36 EST by System User on behalf of Queensland Brain Institute