Cough-related neural processing in the brain: a roadmap for cough dysfunction?

Ando, Ayaka, Farrell, Michael J. and Mazzone, Stuart B. (2014) Cough-related neural processing in the brain: a roadmap for cough dysfunction?. Neuroscience and Biobehavioral Reviews, 47 457-468. doi:10.1016/j.neubiorev.2014.09.018


Author Ando, Ayaka
Farrell, Michael J.
Mazzone, Stuart B.
Title Cough-related neural processing in the brain: a roadmap for cough dysfunction?
Journal name Neuroscience and Biobehavioral Reviews   Check publisher's open access policy
ISSN 1873-7528
0149-7634
Publication date 2014-11-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neubiorev.2014.09.018
Open Access Status
Volume 47
Start page 457
End page 468
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2015
Language eng
Abstract Cough is a complex respiratory behavior essential for airway protection, consisting of sensory, motor, affective and cognitive attributes. Accordingly, the cough neural circuitry extends beyond a simple pontomedullary reflex arc to incorporate a network of neurons that are also widely distributed throughout the subcortical and cortical brain. Studies have described discrete regional responses in the brain that likely give rise to sensory discriminative processes, voluntary and urge-related cough control mechanisms and aspects of the emotive responses following airways irritation and coughing. Data from these studies highlight the central nervous system as a plausible target for therapeutic intervention and, consistent with this, a careful appraisal of the many and varied clinical disorders of coughing control would argue that more diversified therapies are needed to treat patients with cough dysfunction. In this paper we explore these concepts in detail to highlight unanswered questions and stimulate discussion for potential research of cough in the future.
Keyword Urge-to-cough
Cough dysfunction
Cough hypersensitivity
fMRI
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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