Self-assembled peptide-polymer conjugates as vaccines

Liu, Tzu-Yu, Fuaad, Abdullah Al-Hadi Ahmad, Toth, Istvan and Skwarczynski, Mariusz (2014) Self-assembled peptide-polymer conjugates as vaccines. Chimica Oggi - Chemistry Today, 32 2 (Supplement): 18-22.

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Name Description MIMEType Size Downloads
Author Liu, Tzu-Yu
Fuaad, Abdullah Al-Hadi Ahmad
Toth, Istvan
Skwarczynski, Mariusz
Title Self-assembled peptide-polymer conjugates as vaccines
Journal name Chimica Oggi - Chemistry Today   Check publisher's open access policy
ISSN 0392-839X
Publication date 2014
Sub-type Article (original research)
Open Access Status
Volume 32
Issue 2 (Supplement)
Start page 18
End page 22
Total pages 5
Place of publication Milan, Italy
Publisher Tekno Scienze
Collection year 2015
Language eng
Abstract Peptide-based vaccines overcome most side effects associated with classical vaccines and elicit a very specific immune response. However, peptides itself are very poor immunogens and must be delivered with an immunostimulant to achieve the desired immune response. Very few adjuvants are available for vaccine formulation because most known adjuvants (usually pathogen-derived) are too toxic for human use. Therefore a delivery system is required to overcome the poor immunogenicity of peptides without causing toxic side effects. Recently, a polymer-based delivery strategy for peptide vaccines was proposed. The delivery platform described herein was able to induce both humoral and cellular immunity against short peptide epitopes to target either Group A Streptococcus infection or cervical cancer.
Keyword Self-adjuvanting
Peptide vaccine
Cervical cancer
Group A streptococcus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Monographic Supplement: Oligos and Peptides

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
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Created: Wed, 05 Nov 2014, 16:10:07 EST by Dr Mariusz Skwarczynski on behalf of School of Chemistry & Molecular Biosciences