Predictors of the use of medications before and during pregnancy

Odalovic, Marina, Kovacevic, Sandra Vezmar, Nordeng, Hedvig, Ilic, Katarina, Sabo, Ana and Tasic, Ljiljana (2013) Predictors of the use of medications before and during pregnancy. International Journal of Clinical Pharmacy, 35 3: 408-416. doi:10.1007/s11096-013-9750-7


Author Odalovic, Marina
Kovacevic, Sandra Vezmar
Nordeng, Hedvig
Ilic, Katarina
Sabo, Ana
Tasic, Ljiljana
Title Predictors of the use of medications before and during pregnancy
Journal name International Journal of Clinical Pharmacy   Check publisher's open access policy
ISSN 2210-7703
2210-7711
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s11096-013-9750-7
Open Access Status
Volume 35
Issue 3
Start page 408
End page 416
Total pages 9
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Formatted abstract
Background
Drug use in pregnancy is often reason of concern for mothers and their physicians. However, only few studies investigated predictors of drug use in pregnancy.

Objectives
To examine maternal characteristics as predictors of medication use in the 6 months before pregnancy and during the first 6 months of pregnancy. To examine whether prescription and over-the-counter (OTC) medication use in the 6 months before pregnancy had an impact on medication use in pregnancy.

Setting
Six maternity care units and five community pharmacies.

Method
Data were collected using a specially designed self-reported questionnaire during the period March 2009-March 2010. Logistic regression was used to identify factors associated with medication use.

Main outcome measure
Adjusted odds ratios (aOR) and 95 % confidence intervals (CI) were used as association measures.

Results
A total of 236 women were included in the analysis. After controlling for maternal characteristics, parity of more than one was associated with lower prescription medication use in pregnancy (aOR 0.46; 95 % CI 0.22-0.93), higher household income with higher OTC medication use before pregnancy (aOR 3.13; 95 % CI 1.22-8.00), and miscarriage with higher C and D Food and Drug Administration (FDA) risk category medication use in pregnancy (aOR 3.65; 95 % CI 1.30-10.25). Prescription medication use before pregnancy was associated with higher prescription medication use in pregnancy (aOR 2.49; 95 % CI 1.12-5.52), OTC medication use before pregnancy with higher OTC medication use in pregnancy (aOR 35.95; 95 % CI 7.95-162.49), and C and D FDA risk category medication use before pregnancy with the same category medication use in pregnancy (aOR 3.54; 95 % CI 1.23-10.17).

Conclusion
Different maternal characteristics were shown as predictors of medication use before and during pregnancy. However, medication use before pregnancy was shown as the most important predicting factor for the medication use in pregnancy.
Keyword Maternal health
Medication use
Pregnancy
Serbia
Socio-economic factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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