Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease

Hilton, Heidi N., Doan, Tram B., Dinny Graham, J., Oakes, Samantha R., Silvestri, Audrey, Santucci, Nicole, Kantimm, Silke, Huschtscha, Lily I., Ormandy, Christopher J., Funder, John W., Simpson, Evan R., Kuczek, Elizabeth S., Leedman, Peter J., Tilley, Wayne D., Fuller, Peter J., Muscat, George E. and Clarke, Christine L. (2014) Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease. Oncotarget, 5 18: 8651-8664.

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Author Hilton, Heidi N.
Doan, Tram B.
Dinny Graham, J.
Oakes, Samantha R.
Silvestri, Audrey
Santucci, Nicole
Kantimm, Silke
Huschtscha, Lily I.
Ormandy, Christopher J.
Funder, John W.
Simpson, Evan R.
Kuczek, Elizabeth S.
Leedman, Peter J.
Tilley, Wayne D.
Fuller, Peter J.
Muscat, George E.
Clarke, Christine L.
Title Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease
Journal name Oncotarget   Check publisher's open access policy
ISSN 1949-2553
Publication date 2014-08-16
Year available 2014
Sub-type Article (original research)
Open Access Status File (Author Post-print)
Volume 5
Issue 18
Start page 8651
End page 8664
Total pages 14
Place of publication Albany, NY, United States
Publisher Impact Journals
Collection year 2015
Language eng
Abstract Cumulative exposure to estrogen (E) and progesterone (P) over the menstrual cycle significantly influences the risk of developing breast cancer. Despite the dogma that PR in the breast merely serves as a marker of an active estrogen receptor (ER), and as an inhibitor of the proliferative actions of E, it is now clear that in the breast P increases proliferation independently of E action. We show here that the progesterone receptor (PR) and ER are expressed in different epithelial populations, and target non-overlapping pathways in the normal human breast. In breast cancer, PR becomes highly correlated with ER, and this convergence is associated with signaling pathways predictive of disease metastasis. These data challenge the established paradigm that ER and PR function co-operatively in normal breast, and have significant implications not only for our understanding of normal breast biology, but also for diagnosis, prognosis and/or treatment options in breast cancer patients.
Keyword Estrogen receptor
Progesterone receptor
Breast cancer
Human breast
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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