Pulsatile contractility of actomyosin networks organizes the cellular cortex at lateral cadherin junctions

Wu, Selwin K., Budnar, Srikanth, Yap, Alpha S. and Gomez, Guillermo A. (2014) Pulsatile contractility of actomyosin networks organizes the cellular cortex at lateral cadherin junctions. European Journal of Cell Biology, 93 10-12: 396-404. doi:10.1016/j.ejcb.2014.09.001


Author Wu, Selwin K.
Budnar, Srikanth
Yap, Alpha S.
Gomez, Guillermo A.
Title Pulsatile contractility of actomyosin networks organizes the cellular cortex at lateral cadherin junctions
Journal name European Journal of Cell Biology   Check publisher's open access policy
ISSN 1618-1298
0171-9335
Publication date 2014-09-16
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.ejcb.2014.09.001
Open Access Status
Volume 93
Issue 10-12
Start page 396
End page 404
Total pages 9
Place of publication Jena, Germany
Publisher Urban und Fischer Verlag
Collection year 2015
Language eng
Abstract The physical properties of cells reflect how the structure and dynamics of the actomyosin cortex are coupled to the plasma membrane. In epithelia, adhesive E-cadherin clusters associate with the cell cortex to assemble the junctional actomyosin that participates in epithelial morphogenesis. E-cadherin is present not only at the apical zonula adherens (ZA), but also distributed throughout the lateral adherens junction (LAJ) below the ZA. However, the organizational dynamics of the actomyosin network at the LAJs remains elusive. To address this, we used quantitative real-time imaging to characterize the dynamics of actomyosin contractility at lateral cadherin contacts. Here, we report that contractility is coordinated into smaller actomyosin rings that link cadherin clusters together within the larger cortical network at the lateral junctions. We conclude that Myosin II activity determines the contractility of actomyosin cables between cadherin clusters to propagate pulsatility across lateral cell–cell contacts.
Keyword Pulsation
Contractility
Actin
Myosin
E-cadherin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 16 September 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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