Oxidative stress during extracorporeal circulation

McDonald, Charles Ian, Fraser, John Francis, Coombes, Jeff S. and Fung, Yoke Lin (2014) Oxidative stress during extracorporeal circulation. European Journal of Cardio-Thoracic Surgery, 46 6: 937-943. doi:10.1093/ejcts/ezt637


Author McDonald, Charles Ian
Fraser, John Francis
Coombes, Jeff S.
Fung, Yoke Lin
Title Oxidative stress during extracorporeal circulation
Journal name European Journal of Cardio-Thoracic Surgery   Check publisher's open access policy
ISSN 1873-734X
1010-7940
Publication date 2014-01-30
Year available 2014
Sub-type Article (original research)
DOI 10.1093/ejcts/ezt637
Open Access Status
Volume 46
Issue 6
Start page 937
End page 943
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2015
Language eng
Abstract There is an increased oxidative stress response in patients having cardiac surgery, haemodialysis or extracorporeal membrane oxygenation that is related to poorer outcomes and increased mortality. Exposure of the patients' blood to the artificial surfaces of these extracorporeal devices, coupled with inflammatory responses, hyperoxia and the pathophysiological aspects of the underlying illness itself, all contribute to this oxidative stress response. Oxidative stress occurs when there is a disruption of redox signalling and loss of control of redox balance. Ongoing oxidative stress occurring during extracorporeal circulation (ECC) results in damage to lipids, proteins and DNA and contributes to morbidity and mortality. This review discusses reactive species generation and the potential clinical consequences of oxidative stress during ECC as well as provides an overview of some current antioxidant compounds that are available to potentially mitigate the oxidative stress response.
Keyword Extracorporeal circulation
Cardiopulmonary bypass
ECMO
Dialysis
Oxidative stress
Antioxidants
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online: January 30, 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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Created: Wed, 29 Oct 2014, 13:23:35 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences