Hyaluronic acid-conjugated mesoporous silica nanoparticles: excellent colloidal dispersity in physiological fluids and targeting efficacy

Ma, Ming, Chen, Hangrong, Chen, Yu, Zhang, Kun, Wang, Xia, Cui, Xiangzhi and Shi, Jianlin (2012) Hyaluronic acid-conjugated mesoporous silica nanoparticles: excellent colloidal dispersity in physiological fluids and targeting efficacy. Journal of Materials Chemistry, 22 12: 5615-5621. doi:10.1039/c2jm15489g


Author Ma, Ming
Chen, Hangrong
Chen, Yu
Zhang, Kun
Wang, Xia
Cui, Xiangzhi
Shi, Jianlin
Title Hyaluronic acid-conjugated mesoporous silica nanoparticles: excellent colloidal dispersity in physiological fluids and targeting efficacy
Journal name Journal of Materials Chemistry   Check publisher's open access policy
ISSN 0959-9428
1364-5501
Publication date 2012-03-28
Year available 2012
Sub-type Article (original research)
DOI 10.1039/c2jm15489g
Open Access Status Not yet assessed
Volume 22
Issue 12
Start page 5615
End page 5621
Total pages 7
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Formatted abstract
Hyaluronic acid-conjugated mesoporous silica nanoparticles (MSNs-HA) have been synthesized via a facile amidation reaction. This novel strategy can efficiently solve the agglomeration problem of MSNs in physiological fluids. The cellular experiments showed that MSNs-HA is capable of selectively targeting specific cancer cells over-expressing the CD44 protein, leading to rapid and concentration-dependent uptake by the cancer cells through the receptor-mediated endocytosis mechanism. In contrast, no selective targeting of MSNs-HA can be found to the CD44 low-expressing cells, such as MCF-7 and L929 cells. The hydrophobic camptothecin (CPT) drug was encapsulated into MSNs-HA, which showed enhanced cytotoxicity to the Hela cells compared to both free CPT and CPT-loaded MSNs-HA in the presence of excess free HA.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Mechanical & Mining Engineering Publications
 
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