Au capped magnetic core/mesoporous silica shell nanoparticles for combined photothermo-/chemo-therapy and multimodal imaging

Ma, Ming, Chen, Hangrong, Chen, Yu, Wang, Xia, Chen, Feng, Cui, Xiangzhi and Shi, Jianlin (2012) Au capped magnetic core/mesoporous silica shell nanoparticles for combined photothermo-/chemo-therapy and multimodal imaging. Biomaterials, 33 3: 989-998. doi:10.1016/j.biomaterials.2011.10.017


Author Ma, Ming
Chen, Hangrong
Chen, Yu
Wang, Xia
Chen, Feng
Cui, Xiangzhi
Shi, Jianlin
Title Au capped magnetic core/mesoporous silica shell nanoparticles for combined photothermo-/chemo-therapy and multimodal imaging
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
1878-5905
Publication date 2012-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2011.10.017
Open Access Status Not yet assessed
Volume 33
Issue 3
Start page 989
End page 998
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Uniform Au NRs-capped magnetic core/mesoporous silica shell nanoellipsoids (Au NRs-MMSNEs) were prepared by coating a uniform layer of Au NRs on the outer surface of a magnetic core/mesoporous silica shell nanostructure, based on a two-step chemical self-assembly process. This multifunctional nanocomposite integrate simultaneous chemotherapy, photo-thermotherapy, in vivo MR-, infrared thermal and optical imaging into one single system. The obtained multifunctional nanoellipsoids showed very low cytotoxicity, and the cancer cell uptake and intracellular location of the nanoellipsoids were observed by confocal laser scanning microscopy and bio-TEM. Importantly, the prepared multifunctional nanoellipsoids showed high doxorubicin loading capacity and pH value-responsive release mainly due to the electrostatic interaction between DOX molecules and mesoporous silica surface. Besides, a synergistic effect of combined chemo- and photo-thermo therapy was found at moderate power intensity of NIR irradiation based on the DOX release and the photothermal effect of Au NRs.
Keyword Drug delivery
Gold nanorod
Mesoporous silica
Photothermal
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Mechanical & Mining Engineering Publications
 
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