Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells

Chen, Yu, Yin, Qi, Ji, Xiufeng, Zhang, Shengjian, Chen, Hangrong, Zheng, Yuanyi, Sun, Yang, Qu, Haiyun, Wang, Zheng, Li, Yaping, Wang, Xia, Zhang, Kun, Zhang, Linlin and Shi, Jianlin (2012) Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells. Biomaterials, 33 29: 7126-7137. doi:10.1016/j.biomaterials.2012.06.059


Author Chen, Yu
Yin, Qi
Ji, Xiufeng
Zhang, Shengjian
Chen, Hangrong
Zheng, Yuanyi
Sun, Yang
Qu, Haiyun
Wang, Zheng
Li, Yaping
Wang, Xia
Zhang, Kun
Zhang, Linlin
Shi, Jianlin
Title Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
1878-5905
Publication date 2012-10-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2012.06.059
Open Access Status Not yet assessed
Volume 33
Issue 29
Start page 7126
End page 7137
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Nano-biotechnology has been introduced into cancer theranostics by engineering a new generation of highly versatile hybrid mesoporous composite nanocapsules (HMCNs) for manganese-based pH-responsive dynamic T1-weighted magnetic resonance imaging (MRI) to efficiently respond and detect the tumor acidic microenvironment, which was further integrated with ultrasonographic function based on the intrinsic unique hollow nanostructures of HMCNs for potentially in vitro and in vivo dual-modality cancer imaging. The manganese oxide-based multifunctionalization of hollow mesoporous silica nanoparticles was achieved by an in situ redox reaction using mesopores as the nanoreactors. Due to the dissolution nature of manganese oxide nanoparticles under weak acidic conditions, the relaxation rate r1 of manganese-based mesoporous MRI-T1 contrast agents (CAs) could reach 8.81 mM-1s-1, which is a 11-fold magnitude increase compared to the neutral condition, and is almost two times higher than commercial GdIII-based complex agents. This is also the highest r1 value ever reported for manganese oxide nanoparticles-based MRI-T1 CAs. In addition, the hollow interiors and thin mesoporous silica shells endow HMCNs with the functions of CAs for efficient in vitro and in vivo ultrasonography under both harmonic- and B-modes. Importantly, the well-defined mesopores and large hollow interiors of HMCNs could encapsulate and deliver anticancer agents (doxorubicin) intracellularly to circumvent the multidrug resistance (MDR) of cancer cells and restore the anti-proliferative effect of drugs by nanoparticle-mediated endocytosis process, intracellular drug release and P-gp inhibition/ATP depletion in cancer cells.
Keyword Cancer therapy
Diagnosis
Hollow
Mesoporous
MRI
Ultrasonography
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Mechanical & Mining Engineering Publications
 
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