Structure-property relationships in manganese oxide - mesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug delivery

Chen, Yu, Chen, Hangrong, Zhang, Shengjian, Chen, Feng, Sun, Shikuan, He, Qianjun, Ma, Ming, Wang, Xia, Wu, Huixia, Zhang, Lingxia, Zhang, Linlin and Shi, Jianlin (2012) Structure-property relationships in manganese oxide - mesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug delivery. Biomaterials, 33 7: 2388-2398. doi:10.1016/j.biomaterials.2011.11.086


Author Chen, Yu
Chen, Hangrong
Zhang, Shengjian
Chen, Feng
Sun, Shikuan
He, Qianjun
Ma, Ming
Wang, Xia
Wu, Huixia
Zhang, Lingxia
Zhang, Linlin
Shi, Jianlin
Title Structure-property relationships in manganese oxide - mesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug delivery
Formatted title
Structure-property relationships in manganese oxide - mesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug delivery
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
1878-5905
Publication date 2012-03
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2011.11.086
Open Access Status Not yet assessed
Volume 33
Issue 7
Start page 2388
End page 2398
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
The extremely low longitudinal relaxivity (r1) of manganese oxide has severely impeded their substitution for cytotoxic gadolinium-based contrast agents for safe clinical magnetic resonance imaging (MRI). Here, we report on a synthetic strategy of chemical oxidation/reduction reaction in-situ in mesopores, followed by hydrogen reduction, for the fabrication of non-toxic manganese oxide/MSNs-based MRI-T1 contrast agents with highly comparable imaging performance to commercial Gd-based agents. This strategy involves a " soft-templating" process to prepare mesoporous silica nanoparticles, in-situ reduction of MnO4- by the " soft templates" in mesopores and heat treatment under reducing atmosphere, to disperse manganese oxide nanoparticles within mesopores. This special nanostructure combines the merits of nanopores for maximum manganese paramagnetic center accessibility for water molecules for enhanced MRI performance and encapsulation/sustained release/intracellular delivery of drugs. The synthesized manganese oxide/MSNs were successfully assessed as a high performance contrast agent for MRI-T1 both in intro and in vivo, and meanwhile, was also demonstrated as an effective anti-cancer drug delivery (doxorubicin) vehicle, therefore, a family of manganese-based theranostics was successfully demonstrated based on the manganese oxide/MSNs composite.
Keyword Diagnosis
Drug delivery
Magnetic resonance imaging
Manganese oxide
Mesoporous silica
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Mechanical & Mining Engineering Publications
 
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