DNA and RNA quadruplex-binding proteins

Brazda, Vaclav, Haronikova, Lucia, Liao, Jack C. C. and Fojta, Miroslav (2014) DNA and RNA quadruplex-binding proteins. International Journal of Molecular Sciences, 15 10: 17493-17517. doi:10.3390/ijms151017493


Author Brazda, Vaclav
Haronikova, Lucia
Liao, Jack C. C.
Fojta, Miroslav
Title DNA and RNA quadruplex-binding proteins
Journal name International Journal of Molecular Sciences   Check publisher's open access policy
ISSN 1422-0067
Publication date 2014-09-29
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/ijms151017493
Open Access Status DOI
Volume 15
Issue 10
Start page 17493
End page 17517
Total pages 25
Place of publication Basel, Switzerland
Publisher M D P I AG
Collection year 2015
Language eng
Abstract Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i-Motifs, minor groove quadruplexes, G-quadruplexes, etc.), the best described are G-quadruplexes which are featured by Hoogsteen base-paring. Sequences with the potential to form quadruplexes are widely present in genome of all organisms. They are found often in repetitive sequences such as telomeric ones, and also in promoter regions and 5' non-coding sequences. Recently, many proteins with binding affinity to G-quadruplexes have been identified. One of the initially portrayed G-rich regions, the human telomeric sequence (TTAGGG)n, is recognized by many proteins which can modulate telomerase activity. Sequences with the potential to form G-quadruplexes are often located in promoter regions of various oncogenes. The NHE III1 region of the c-MYC promoter has been shown to interact with nucleolin protein as well as other G-quadruplex-binding proteins. A number of G-rich sequences are also present in promoter region of estrogen receptor alpha. In addition to DNA quadruplexes, RNA quadruplexes, which are critical in translational regulation, have also been predicted and observed. For example, the RNA quadruplex formation in telomere-repeat-containing RNA is involved in interaction with TRF2 (telomere repeat binding factor 2) and plays key role in telomere regulation. All these fundamental examples suggest the importance of quadruplex structures in cell processes and their understanding may provide better insight into aging and disease development.
Keyword DNA quadruplex
RNA quadruplex
Telomere
Protein–DNA binding
Regulation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Official Audit
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 28 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 28 Oct 2014, 00:23:35 EST by System User on behalf of School of Medicine