Elimination of climbing fiber instructive signals during motor learning

Ke, Michael C., Guo, Cong C. and Raymond, Jennifer L. (2009) Elimination of climbing fiber instructive signals during motor learning. Nature Neuroscience, 12 9: 1171-1179. doi:10.1038/nn.2366

Author Ke, Michael C.
Guo, Cong C.
Raymond, Jennifer L.
Title Elimination of climbing fiber instructive signals during motor learning
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1097-6256
Publication date 2009
Year available 2009
Sub-type Article (original research)
DOI 10.1038/nn.2366
Open Access Status
Volume 12
Issue 9
Start page 1171
End page 1179
Total pages 9
Place of publication New York, NY United States
Publisher Nature Publishing Group
Collection year 2009
Language eng
Subject 2800 Neuroscience
Abstract The climbing fiber input to the cerebellum from the inferior olive is thought to act as a teacher whose activity controls the induction of motor learning. We designed training conditions that did not elicit instructive signals in the climbing fibers, but nevertheless induced robust and consistent motor learning in the vestibulo-ocular reflex of rhesus monkeys. Our results indicate that instructive signals in the climbing fibers are not necessary for cerebellum-dependent learning. Instead, instructive signals carried by either the climbing fibers or Purkinje cell simple spikes may be sufficient to induce motor learning, with additive effects occurring when both instructive signals are present during training.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Architecture Publications
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 44 times in Scopus Article | Citations
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Created: Mon, 27 Oct 2014, 20:04:02 EST by Sylvie Pichelin on behalf of School of Architecture