Physiological roles of ion channels in adult neural stem cells and their progeny

Yasuda, Takahiro and Adams, David J. (2010) Physiological roles of ion channels in adult neural stem cells and their progeny. Journal of Neurochemistry, 114 4: 946-959. doi:10.1111/j.1471-4159.2010.06822.x


Author Yasuda, Takahiro
Adams, David J.
Title Physiological roles of ion channels in adult neural stem cells and their progeny
Journal name Journal of Neurochemistry   Check publisher's open access policy
ISSN 0022-3042
1471-4159
Publication date 2010
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1471-4159.2010.06822.x
Open Access Status
Volume 114
Issue 4
Start page 946
End page 959
Total pages 14
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Collection year 2010
Language eng
Subject 1303 Specialist Studies in Education
2804 Cellular and Molecular Neuroscience
Abstract Elucidation of the machinery of adult neurogenesis is indispensable for the treatment of neurodegenerative diseases by therapeutic drugs andor by neural stem cell (NSC) transplantation. It is well known that membrane ion channels play a critical role in cell function, including proliferation, apoptosis and migration in a wide range of cells. In NSC research, interdisciplinary collaboration between cell biologists and membrane physiologists has been pursued principally to monitor ion channel and synaptic currents as a hallmark of neuronal differentiation and maturation of NSC progeny. Nevertheless, less attention had been paid to a functional role of ion channels in NSCs or their immature progeny. Recently, however, evidence regarding their functional relevance has started to accumulate. In focusing on the early stages of the neurogenic process during which NSCs give rise to neuroblasts, this review highlights the latent ability of ion channels to act as functional regulators of adult neurogenesis. © 2010 The Authors. Journal Compilation
Keyword Adult neurogenesis
Ion channel
Neural stem cell
Neuroblast
Proliferation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 27 Oct 2014, 19:24:07 EST by Sylvie Pichelin on behalf of Queensland Brain Institute