Are nicotinic acetylcholine receptors coupled to G proteins?

Kabbani, Nadine, Nordman, Jacob C., Corgiat, Brian A., Veltri, Daniel P., Shehu, Amarda, Seymour, Victoria A. and Adams, David J. (2013) Are nicotinic acetylcholine receptors coupled to G proteins?. BioEssays, 35 12: 1025-1034. doi:10.1002/bies.201300082

Author Kabbani, Nadine
Nordman, Jacob C.
Corgiat, Brian A.
Veltri, Daniel P.
Shehu, Amarda
Seymour, Victoria A.
Adams, David J.
Title Are nicotinic acetylcholine receptors coupled to G proteins?
Journal name BioEssays   Check publisher's open access policy
ISSN 0265-9247
Publication date 2013-12
Sub-type Article (original research)
DOI 10.1002/bies.201300082
Open Access Status
Volume 35
Issue 12
Start page 1025
End page 1034
Total pages 10
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Formatted abstract
It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding to G proteins modulates the activity and signaling of nAChRs in cells. It is important to note that while this hypothesis is new for the nAChR, it is consistent with known interactions between G proteins and structurally related ligand-gated ion channels. Therefore, it underscores an evolutionarily conserved metabotropic mechanism of G protein signaling via nAChR channels.
Keyword Acetylcholine
G protein coupling
Intracellular loop
Ligand-gated ion channel
Loop modeling
Protein interaction
Signal transduction
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Mon, 27 Oct 2014, 17:57:13 EST by Sylvie Pichelin on behalf of Queensland Brain Institute